Page 57 - CIBERSAM2016-ENG

Some of these research lines are developed in close collaboration with other national research groups (CIBER: CIBERSAM and CIBERER) and International research groups, under the coordination of G08 researchers and with some new funded projects:
• Maternal prenatal stress and HPA axis sensitization mediated by 11ß-HSD2 gene epigenetic signatures
and its interplay with childhood psychosocial stress in explaining risk for psychopathology in
adolescence. (PINT1512_IP L. Fañanás (G8)+G1+G4+G5+G22+ Ciberer-U719r+MHI of Manheim.
• Brain development and early stressful conditions in mental Health: the mediating role of epigenètic
mechanisms and neuroimaging correlates (ES-EUEpiBrain) SAF2015-71526-REDT_MINECO Acciones de Dinamización “Redes de Excelencia”_IP.L.Fañanas (G8)+G4+G24+G25+Ciberer-U719+MHI of Manheim+ U Paris Descartes+ U Medical Center Utrech+U of Milan.
Most relevant scientific articles
• Cordova-Palomera A., Tornador C., Falcon C., Bargallo N., Brambilla P., Crespo-Facorro B. et al. Environmental factors linked to depression vulnerability are associated with altered cerebellar resting- state synchronization. Scientific Reports. 2016;6.
• Cordova-Palomera A., de Reus M.A., Fatjo-Vilas M., Falcon C., Bargallo N., van Den Heuvel M.P. et al. FKBP5 modulates the hippocampal connectivity deficits in depression: a study in twins. Brain Imaging and Behavior. 2016;1-14.
• Peralta V, Goldberg X, Ribeiro M, Sanchez-Torres AM, Fañanás L, Cuesta MJ. Familiality of Psychotic Disorders: A Polynosologic Study in Multiplex Families.Schizophrenia bulletin. 2016.
• Prats C., Arias B., Moya-Higueras J., Pomarol-Clotet E., Parellada M., Gonzalez-Pinto A. et al. Evidence of an epistatic effect between Dysbindin-1 and Neuritin-1 genes on the risk for schizophrenia spectrum disorders. European Psychiatry. 2016; 40:60-64.
• Soler J, Miret S, Lázaro L, Parellada M, Martín M, Lera-Miguel S et al. Influence of DAOA and RGS4 genes on the risk for psychotic disorders and their associated executive dysfunctions: A family-based study.European psychiatry : the journal of the Association of European Psychiatrists. 2016; 32:42-7.
Hightlights
The most relevant results of our group during 2016 are, on the one hand, the identified relationship between genetic variants in the FKBP5 gene and deficits in hippocampal connectivity in patients with depression. In addition, these patients seem to show alterations in cerebellum synchronization processes in resting state. Our designs, based on informative samples of monozygotic twins, have allowed us to attribute this alteration to non- shared environmental risk factors in pairs.
On the other hand, and with the collaboration of some CIBERSAM groups, different synaptic plasticity genes have been analysed in relation to the risk for psychosis and, especially, the role that some of these most significant variants might have on vulnerability to schizophrenia, its age of onset and altered cognitive functions. In this regard, it has been possible to demonstrate the epistasis between the DTNBP1-1 and NRN1 genes on the risk for schizophrenia and spectrum disorders, and the role of the NRN1 gene on the early onset of these disorders and on the presence of some cognitive deficits.
New research projects focused on the study of neurobiological mechanisms altered by exposure to child maltreatment have been established with the Central Institute of Mental Health in Mannheim. This new project has been linked to the multicenter FIS study PI15 / 00097 “Multicenter study of child maltreatment in children and adolescents with psychiatric disorders: epigenetic modifications and correlates with peripheral markers of innate immunity”, coordinated by our group, in which several CIBERSAM groups are involved.
SAM
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