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leaD reSearcHer
Leza Cerro, Juan Carlos
Universidad Complutense de Madrid
Facultad de Medicina Pza. Ramón y Cajal, s/n. Ciudad Universitaria 28040 Madrid
(+34) 91 394 14 78 [email protected] group website
GROUP MEMBERS
Staff members: Macdowell Mata, Karina
Associated members: Carrasco Perera, José Luis | Díaz Marsa, Marina | García Bueno, Borja | Muñoz Madrigal, José Luis | Rodríguez Maus, Sandra | Sayd, Aline
Main lines of research
• Search for inflammatory biomarkers in plasma and peripheral blood mononuclear cells from neuropsychiatric diseases (depression, schizophrenia, bipolar disease) in order to identify and develop new therapeutic strategies.
• Potential new mechanisms: role of innate immunity receptors (TLRs) in stress-related processes in experimental models of neuro-psychiatric pathologies and in humans with depression, schizophrenia, autism spectrum disorders and ethanol abuse.
• Identification of possible trait or status biomarkers in eating disorders and in impulse control disorders.
• Regulatory intra and inter cellular mechanisms of noradrenaline and chemokines as anti-inflammatory
mediators in experimental models and in patients with Alzheimer disease.
• Study of the mechanisms of brain passing of signaling molecules and the role of some blood brain
barrier cells in its regulation.
• Study on protective mechanisms against oxidative and inflammatory cellular damage in experimental
models of psychopathologies. Neuroprotective strategies.
• Study on intestinal translocation of bacteria in experimental models and in patients with depression,
schizophrenia and autism spectrum disorders.
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PROGRAMMES
Psychosomatic, Anxiety
and Impulse Control Disorders Therapeutic Innovation