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• Evaluation of the therapeutic potential of the endocannabinoid system in first episode psychosis and other psychiatric diseases.
• Evaluation of the therapeutic potential of the endocannabinoid system in gastrointestinal pathologies related with stress exposure.
• Search for novel antiinflammatory/antioxidant mechanisms of antidepressants and antipsychotics in experimental models (in vivo and in vitro).
Most relevant scientific articles
• Martin-Hernandez D., Caso J.R., Bris A.G., Maus S.R., Madrigal J.L.M., Garcia-Bueno B. et al. Bacterial translocation affects intracellular neuroinflammatory pathways in a depression-like model in rats. Neuropharmacology. 2016; 103:122-133.
• Bioque M., Cabrera B., Garcia-Bueno B., Mac-Dowell K.S., Torrent C., Saiz P.A. et al. Dysregulated peripheral endocannabinoid system signaling is associated with cognitive deficits in first-episode psychosis. Journal of Psychiatric Research. 2016; 75:14-21.
• García-Bueno B, Gassó P, MacDowell KS, Callado LF, Mas S, Bernardo M et al. Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia.Journal of psychiatry & neuroscience : JPN. 2016;41(3):150195.
• Garcia Bueno B., Caso J.R., Madrigal J.L.M., Leza J.C. Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases. Neuroscience and Biobehavioral Reviews. 2016; 64:134-147.
• MacDowell K.S., Caso J.R., Martin-Hernandez D., Moreno B.M., Madrigal J.L.M., Mico J.A. et al. The Atypical Antipsychotic Paliperidone Regulates Endogenous Antioxidant/Anti-Inflammatory Pathways in Rat Models of Acute and Chronic Restraint Stress. Neurotherapeutics. 2016:1-11.
Hightlights
Dr. Leza leads a stable and consolidated group. During the year 2016, new public and private funds have been granted (MINECO SAF, Fund. Santander-UCM).
This group is also characterized by its active involvement in teaching and training of new researchers, receiving in the last year both national and international undergraduate, master, doctorate and postgraduate students. Leza’s group maintains its commitment to the co-organization of the “young scientists’ ideas laboratory” annual meeting.
Finally, this group is committed to the diffusion and search of collaborations between the different groups of CIBERSAM and other consortia.
SAM
research groups 63