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Most relevant scientific articles
• Linge R, Jiménez-Sánchez L, Campa L, Pilar-Cuéllar F, Vidal R, Pazos A et al. Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors.Neuropharmacology. 2016; 103:16-26.
• Amigó J, Díaz A, Pilar-Cuéllar F, Vidal R, Martín A, Compan V et al. The absence of 5-HT4 receptors modulates depression- and anxiety-like responses and influences the response of fluoxetine in olfactory bulbectomised mice: Adaptive changes in hippocampal neuroplasticity markers and 5-HT1A autoreceptor.Neuropharmacology. 2016.
• Ferres-Coy A., Galofre M., Pilar-Cuellar F., Vidal R., Paz V., Ruiz-Bronchal E. et al. Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration. Molecular Psychiatry. 2016;21(3):328-338.
• Jimenez-Sanchez L., Linge R., Campa L., Valdizan E.M., Pazos A., Diaz A. et al. Behavioral, neurochemical and molecular changes after acute deep brain stimulation of the infralimbic prefrontal cortex. Neuropharmacology. 2016; 108:91-102.
• España-Serrano L, Guerra Martín-Palanco N, Montero-Pedrazuela A, Pérez-Santamarina E, Vidal R, García-Consuegra I et al. The Addiction-Related Protein ANKK1 is Differentially Expressed During the Cell Cycle in Neural Precursors.Cerebral cortex (New York, N.Y.: 1991). 2016.
Hightlights
During 2016, our group has focused on: (1) the study of fast acting antidepressants. In this sense, we
are working in a nationally financed project (SAF2015-67457-R) for the study of the neuroplastic and neurochemical mechanisms of action involved in the rapid antidepressant effect of the phytocannabinoid compound cannabidiol. This compound exhibits an important anti-inflammatory effect. Therefore, we are evaluating cannabidiol actions in a neuroinflammatory animal model of depression. Additionally, we are involved in a collaborative study on deep brain stimulation as a rapid and effective antidepressant therapy. (2) On the other hand, we are studying novel therapeutic targets for the treatment of depression, specially evaluating mTOR and Wnt/ß-catenin pathways, involved in neuroplasticity, to understand their contribution to the neurobiology of depression and antidepressant effects. (3) Finally, another relevant lines are the study of the implication of serotonergic 5-HT4 in 5-HT1A receptors by using animal models of depression.
Our group also has an important dedication to the coordination of the “Máster Interuniversitario de Iniciación a la Investigación en Salud Mental”.
SAM
research groups 75